The life of Queen Insoo from her childhood to adulthood as she ruled Joseon alongside her mother-in-law, Queen Jeonghee. The drama spans from King Moon Jong to Yeon San, Insoo's grandson.

The Story is centered on the love between a musically gifted South Korean man, Sung-jae Jo Hyun Jae, and a Japanese woman, Misaki Nakagoshi Noriko. Misaki, who feels guilty over her boyfriend's death, is transferred to Korean and meets Seong-jae who helps her cure her wounds of the past memories with love.